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Cmet rna car t cells

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Cmet rna car t cells - a preparation of autologous t-lymphocytes that have been electroporated with an mrna encoding a chimeric antigen receptor (car) consisting of an anti-human hepatocyte growth factor receptor (hgfr or cmet) scfv (single chain variable fragment) and the zeta chain of the tcr/cd3 complex (cd3-zeta) coupled to the co-stimulatory molecule 4-1bb (cd137), with potential antineoplastic activities. Upon intratumoral administration, cmet car-mrna electroporated autologous t lymphocytes direct t-cells to cmet-expressing tumor cells, which induces a selective toxicity in cmet-expressing tumor cells and causes tumor cell lysis. The 4-1bb co-stimulatory molecule signaling domain enhances activation and signaling after recognition of cmet. The inclusion of the 4-1bb signaling domain may increase the antitumor activity as compared to the inclusion of the cd3-zeta chain alone. The mrna car is expressed for a limited amount of time, which can prevent serious, unforeseen side effects. Cmet, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis. See cmet car-mrna electroporated autologous t lymphocytes

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