Cni inhibitor - any agent that inhibits calcineurin (protein phosphatase 3; ppp3), a serine/threonine protein phosphatase dependent on calcium and calmodulin, with immunosuppressant activity. Inhibition of calcineurin prevents dephosphorylation of the transcription factor nuclear factor of activated t-cells, cytoplasmic (nfatc), which prevents its translocation to the nucleus and the subsequent induction of the expression of interleukin-2 (il-2). This prevents il-2-mediated proliferation and activation of t-cells, and t-lymphocyte-mediated immune responses. See calcineurin inhibitor
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