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Cobblestone forming units

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Cobblestone forming units - the number of hematopoietic stem cells (hscs) that migrate between or beneath a co-cultured feeder cell layer and become trapped. When hscs are cultured with a feeder layer and observed using phase contrast microscopy, the trapped cells appear less spherical and less refractile than the hscs that are floating loosely on top of the feeder layer. See cobblestone area-forming cells

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