From WikiMD
Jump to navigation Jump to search

Information about Codeine

Codeine is one of the natural plant alkaloids found in extracts of opium and is commonly used to treat mild-to-moderate pain and cough.

Liver safety of Codeine

Codeine, like other opioids, has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.

Mechanism of action of Codeine

Codeine (koe’ deen) is a natural alkaloid derived from resin extracts from the seeds of the opium poppy, Papaver somniferum. Codeine has opiate-like analgesic effects, but is much less potent than morphine. Codeine, however, is well absorbed orally and is less likely to cause serious respiratory depression than morphine. Codeine has been used in clinical medicine for more than a century and is currently approved for use in the United States as an oral analgesic for mild-to-moderate pain and, in low doses, as an antitussive for suppression of nonproductive cough.

Dosage and administration for Codeine

Codeine is available in multiple formulations including oral tablets of 15, 30 and 60 mg, as well as oral solutions and solutions for injection (subcutaneously, intramuscularly, intravenously) in varying concentrations. The typical adult, oral dose of codeine for analgesia is 15 to 60 mg every 4 to 6 hours. In addition, multiple commercial products combining codeine with acetaminophen for therapy of mild-to-moderate pain are available generically and under brand names such as Codrix and Codet. Side effects of codeine include sedation, respiratory depression, mental clouding, euphoria, agitation, constipation, abdominal bloating, nausea, vomiting and constipation. Codeine is a controlled substance and classified as a Schedule III drug, indicating that it has medical usefulness, but also a potential for physical and psychological dependency and abuse. Codeine is also available in low concentrations (~12 mg/tablet) in combination with antihistamines, antitussants or sympathomimetic agents for symptomatic therapy of upper respiratory infections and cough. These products are typically available over-the-counter without prescription.

Full and partial opiod agonists:

Opiate antagonists:

Cost and Coupons - Codeine

Reviews for Codeine

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Articles on Codeine

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Codeine

Drug classes

WikiMD resources 360 on Codeine - scientific articles to social media


Policies / Guidelines Social Media


Patient Resources / Community
Facebook posts

Evidence Based Medicine

Healthcare Provider Resources
YouTube videos

Clinical Trials

External:W8MD Weight Loss, Sleep & MedSpa Wellness Topics A-Z Other resources

A | B | C | D | E | F | G

H | I | J | K | L | M | N

O | P | Q | R | S | T | U

V | W | X | Y | Z

Ad. Tired of being overweight? W8MD's insurance weight loss* program can HELP | Advertise on WikiMD

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary.