Doctor in scrubs


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
28,860 pages, 4,107,174 edits & 35,652,376 views.

Free unbiased diet, health and wellness info!

Sulfasalazine

From WikiMD's free health, diet & wellness encyclopedia
(Redirected from Colo-Pleon)
Jump to navigation Jump to search
Sulfasalazine
Sulfasalazine

Information about Sulfasalazine

Sulfasalazine is an antiinflammatory agent used extensively in chronic, long term therapy of inflammatory bowel disease. Sulfasalazine is structurally composed of a sulfonamide (sulfapyridine) and 5-aminosalacyclic acid (5-ASA) joined by an azo bond.

Sulfasalazine
Sulfasalazine

Liver safety of Sulfasalazine

Sulfasalazine is a rare, but well known cause of idiosyncratic liver injury.

Mechanism of action of Sulfasalazine

Sulfasalazine is a modified sulfonamide composed of sulfapyridine that is covalently linked to 5-aminosalacyclic acid (5-ASA). Sulfasalazine is poorly absorbed, but its azo bond is broken by bacteria in the bowel lumen releasing sulfapyridine that is absorbed and 5-ASA, which reaches high levels and acts locally decreasing inflammation.

FDA approval information for Sulfasalazine

Sulfasalazine was approved for clinical use in the United States in 1950 and is still commonly used.

Clinical use of Sulfasalazine

Current indications are for treatment of active ulcerative colitis and prevention of relapses in disease, both in adults and children. Sulfasalazine is also used for juvenile or adult rheumatoid arthritis. Sulfasalazine is available in generic forms in 500 mg tablets and under the commercial name Azulfidine. Extended release forms are also available. The usual dose in adults is 3 to 4 grams daily initially, with maintenance dosage of 2 grams daily (4 divided doses).

Side effects of Sulfasalazine

Common side effects include anorexia, headache, nausea, gastrointestinal upset, fever, arthralgias and rash.

The following are sulfonamide drugs

Cost and Coupons - Sulfasalazine

Reviews for Sulfasalazine

Learn more about Sulfasalazine

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

This WikiMD article Sulfasalazine is a stub.
If you are a healthcare professional familiar with the topic Sulfasalazine, or
A subject matter expert or authority on Sulfasalazine, you can help us.
About | Mission | Paid editors welcome!

Sulfasalazine is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP*
Special: W8MD's tele-weight loss consultations only $99.99. Call 718-946-5500. Limited acceptance.