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Combotox
Combotox - a combination preparation of 1:1 mixture of two immunotoxins, hd37 dga and rfb4 dga, with potential antineoplastic activity. Both anti cd19 igg monoclonal antibody hd37 and anti cd22 igg monoclonal antibody rfb4 are attached to a single deglycosylated ricin a chain (dga) via n succinimidyl oxycarbonyl alpha methyl alpha (2 pyridyldithio) toluene (smpt) linker. Cd19 and cd22 molecules are cell suface antigens present on the majority of b acute lymphoblastic leukemia cells. This combination agent is able to specifically recognize and bind to cd19 and cd22 expressing tumor cells, thereby targeting the delivery of the cytotoxic ricin a chain to leukemia cells expressing these antigens. Ricin a chain is toxic to ribosomal activity and protein synthesis, and inhibits cell growth.
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