W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
15,602 pages, 4,131,460 edits & 37,452,872 views.

Free unbiased diet, health and wellness info!

Combotox

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Combotox - a combination preparation of 1:1 mixture of two immunotoxins, hd37 dga and rfb4 dga, with potential antineoplastic activity. Both anti cd19 igg monoclonal antibody hd37 and anti cd22 igg monoclonal antibody rfb4 are attached to a single deglycosylated ricin a chain (dga) via n succinimidyl oxycarbonyl alpha methyl alpha (2 pyridyldithio) toluene (smpt) linker. Cd19 and cd22 molecules are cell suface antigens present on the majority of b acute lymphoblastic leukemia cells. This combination agent is able to specifically recognize and bind to cd19 and cd22 expressing tumor cells, thereby targeting the delivery of the cytotoxic ricin a chain to leukemia cells expressing these antigens. Ricin a chain is toxic to ribosomal activity and protein synthesis, and inhibits cell growth.

Up to date info

UpToDate

Latest research - Combotox

PubMed
Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Combotox for any updates.

 

Combotox is part of WikiMD's free ^articles!

^Combotox (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available