Common disease-common variant
Common disease-common variant (CD-CV)
Common disease-common variant (/ˈkɒmən diːˈziːz kɒmən ˈveəriənt/) is a hypothesis in genetic epidemiology that suggests common diseases are often caused by common genetic variants.
Etymology
The term "Common disease-common variant" is derived from the concept that common diseases are often associated with genetic variants that are common in the population.
Definition
The Common disease-common variant hypothesis posits that the genetic risk for common diseases is often due to the cumulative effect of common genetic variants, each of which contributes a small amount to the overall risk. These common genetic variants are often referred to as single nucleotide polymorphisms (SNPs).
Related Terms
- Genetic variant: A difference in the DNA sequence that makes up a gene.
- Single nucleotide polymorphisms: A type of genetic variant that involves a change in a single nucleotide.
- Genetic epidemiology: The study of how genetic factors contribute to health and disease in families and populations.
- Genome-wide association study: A study that involves rapidly scanning markers across the complete sets of DNA, or genomes, of many people to find genetic variations associated with a particular disease.
See Also
External links
- Medical encyclopedia article on Common disease-common variant
- Wikipedia's article - Common disease-common variant
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