COMP

COMP (or Cartilage Oligomeric Matrix Protein) is a protein that in humans is encoded by the COMP gene. It is a non-collagenous extracellular matrix protein and is a major component of the cartilage extracellular matrix.

Pronunciation

COMP is pronounced as /kɒmp/.

Etymology

The term COMP is an acronym derived from the words Cartilage Oligomeric Matrix Protein.

Function

COMP is involved in the formation of cartilage and bone in the body. It plays a crucial role in the development and maintenance of cartilage and bone structure. COMP is also involved in the interaction between chondrocytes and the extracellular matrix.

Clinical significance

Mutations in the COMP gene are associated with Pseudoachondroplasia and Multiple Epiphyseal Dysplasia, two skeletal disorders characterized by short stature and early-onset osteoarthrosis.

Related terms

• Protein
• Gene
• Cartilage
• Bone
• Chondrocyte
• Pseudoachondroplasia
• Multiple Epiphyseal Dysplasia

See also

• Extracellular matrix
• Osteoarthrosis

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