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Conformation dependent mutation detection

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Conformation dependent mutation detection - polymorphism, single stranded conformational, detection. Altered migration of single stranded dna molecules in non denaturing gels based upon 3 d conformation. Uses pcr and/or restriction enzymes to generate short dsdna molecules spanning a sequence of interest. The dsdna molecules are heat denatured, and then quickly cooled. Each ssdna molecule will assume a secondary structure (conformation) dependent upon its unique sequence. Base mutations will often result in altered conformations, with altered mobilities, which can be visualized following separation in non denaturing gels. (nci/osp)

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