De novo variant

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De novo variant
TermDe novo variant
Short definitionDe novo variant - (pronounced) (deh NOH-voh VAYR-ee-unt) term used to describe a change in a gene's DNA sequence that is first seen in a person and has not occurred in previous generations. A de novo variant can explain how a person can have a genetic condition that did not occur in their parents. 
TypeCancer terms
SpecialtyOncology
LanguageEnglish
SourceNCI
Comments


De novo variant - (pronounced) (deh NOH-voh VAYR-ee-unt) term used to describe a change in a gene's DNA sequence that is first seen in a person and has not occurred in previous generations. A de novo variant can explain how a person can have a genetic condition that did not occur in their parents. A de novo variant can occur in an egg or sperm cell from a parent, in the fertilized egg cell shortly after the union of the egg cell and sperm cell, or in another cell type during embryonic development. A person who has a de novo variant can pass the mutation on to their child. Some de novo variants can lead to cancer or other diseases. Also called de novo mutation, new mutation and new variant

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