Logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,590 pages, 4,139,114 edits & 37,811,477 views.

Free unbiased diet, health and wellness info!

Decitabine

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Decitabine

Decitabine is a cytosine analogue and an intravenously administered antineoplastic agent used in the therapy of myelodysplastic syndromes. 

Decitabine
Decitabine

Liver safety of Decitabine

Decitabine is associated with a low rate of transient serum enzyme elevations during therapy, but has not been implicated in causing clinically apparent liver injury with jaundice.

Mechanism of action of Decitabine

Decitabine (dee sye' ta been) is a pyrimidine analogue (5-aza-deoxy-cytidine) which is the deoxyribose form of 5-azacitidine.  Decitabine is converted intracellularly to a triphosphate which becomes incorporated into DNA and appears to inhibit DNA methylation, resulting in increased expression of silenced genes including tumor suppressor genes.  Studies done in vitro and in vivo have shown that decitabine induces differentiation of bone marrow cells and results in normalization of bone marrow in a proportion of patients with myelodysplasia. 

FDA approval information for Decitabine

Decitabine was approved for use in the United States in 2006 and the current single indication is for therapy of myelodysplasic syndromes. 

Dosage and administration for Decitabine

Decitabine is available as a powder or solution for injection in 50 mg vials under the trade name of Dacogen.  The usual dosage regimen in adults is 15 to 20 mg per meter-squared body surface area given intravenously in several day regimens, with repeat cycles every 4 or 6 weeks.  A minimum of 4 courses is recommended. 

Side effects of Decitabine

Common side effects include bone marrow suppression, nausea, vomiting, diarrhea, stomatitis, bruising, abdominal pain, myalgias, headache, dizziness, fatigue, fever, rash and pruritus.

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

 

Cost and Coupons - Decitabine

Reviews for Decitabine

Learn more about Decitabine

Latest research - Decitabine

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Decitabine is a stub. If you are familiar with the topic Decitabine, you can help us. Paid editors welcome!

 

Decitabine is part of WikiMD's free ^articles!

^Decitabine (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available