Delafloxacin

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Information about Delafloxacin

Delafloxacin is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria as well as atypical pathogens.

Liver safety of Delafloxacin

Delafloxacin has been linked to mild ALT elevations during therapy, but has yet to be linked to instances of idiosyncratic acute liver injury with symptoms and jaundice as have been described with other fluoroquinolones.

Mechanism of action of Delafloxacin

Delafloxacin (del" a flox' a sin) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria including multidrug resistant strains of Streptococcus pneumoniae. Like other fluoroquinolones, delafloxacin is active against a wide range of aerobic gram-positive and gram-negative organisms. The quinolones are believed to act by inhibition of type II DNA topoisomerases (gyrases) that are required for synthesis of bacterial mRNAs (transcription) and DNA replication.

FDA approval information for Delafloxacin

Delafloxacin was approved for use in the United States in 2018 and is available under the commercial name Baxdela. Current indications are limited to skin and skin structure infections due to sensitive organisms.

Dosage and administration for Delafloxacin

Delafloxacin is available in both oral and parenteral formulations as 450 mg tablets and as 300 mg of a lyophilized powder in a single dose vial for reconstitution. The recommended regimen is an oral dose of 450 mg every 12 hours or by intravenous infusion every 12 hours for 5 to 14 days.

Side effects of Delafloxacin

  • Common side effects include gastrointestinal upset, nausea, diarrhea, headache, skin rash and allergic reactions.
  • Less common, but more severe side effects of delafloxacin that are shared by other fluoroquinolones include seizures, hallucinations, peripheral neuropathy, tendon rupture, angioedema, photosensitivity and Clostridium difficile-associated diarrhea.

List of flouroquinolones

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