Desipramine

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Information about Desipramine

Desipramine is an oral tricyclic antidepressant that widely used in the therapy of depression.

Liver safety of Desipramine

Desipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.

Mechanism of action of Desipramine

Desipramine is a dibenzazepine derived tricyclic antidepressant which acts by inhibition of serotonin and norepinephrine reuptake within synaptic clefts in the central nervous system, thus increasing brain levels of these neurotransmitters.

FDA approval information for Desipramine

Desipramine is indicated for therapy of depression and was approved for this indication in the United States in 1964.

Dosage and administration for Desipramine

Desipramine is available in generic forms and under the brand names of Norpramin in 10, 25, 50, 75, 100 and 150 mg tablets. The usual recommended dose for depression in adults is 100 to 200 mg daily in one or two divided doses. Desipramine can also be given as a single nighttime dose.

Side effects of Desipramine

Common side effects of tricyclic antidepressants include dizziness, headache, insomnia, somnolence, restlessness, confusion, gastrointestinal upset, increased appetite, weight gain, blurred vision, dry mouth and urinary retention.

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone


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