Logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,990 pages, 4,158,277 edits & 43,278,125 views.

Free unbiased diet, health and wellness info!

Desloratadine

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search
Desloratadine
Desloratadine

Information about Desloratadine

Loratadine and its metabolic derivative desloratadine are second generation antihistamines that are used for the treatment of allergic rhinitis, angioedema and chronic urticaria.

Desloratadine
Desloratadine

Liver safety of Desloratadine

Loratadine and desloratadine have been linked to rare, isolated instances of clinically apparent acute liver injury.

Mechanism of action of Desloratadine

Loratadine (lor at' a deen) and desloratadine (des" lor at' a deen) are second generation antihistamines (H1 receptor blockers) that are used widely to treat allergic symptoms associated with hay fever, seasonal allergies, urticaria, angioedema and atopic dermatitis.

Clinical use of Desloratadine

Like other second generation antihistamines, loratadine and desloratadine are considered to be nonsedating, and prospective studies have shown that sedation is less common with them than first generation antihistamines such as diphenhydramine. Loratadine and desloratadine belong to the piperidine class of antihistamines (similar to fexofenadine). The two agents appear to have a similar spectrum of activity and side effects, although some patients are found to prefer one over the other.

FDA approval information for Desloratadine

Loratadine was approved for use by prescription in the United States in 1993 and as an over-the-counter medication in 2002. It is available in 5 and 10 mg tablets and capsules generically and under the trade name Claritin.

Dosage and administration for Desloratadine

The typical dose is 10 mg once daily and it is often given chronically, at least during allergic season. Desloratadine, which is the major metabolite of loratadine, was approved for use in the United States in 2001 and is currently available by prescription only in tablets of 2.5 or 5 mg in multiple generic forms and under the trade name Clarinex.

Side effects of Desloratadine

Common side effects of second generation antihistamines include blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache. Although considered to be nonsedating antihistamines, loratadine and desloratadine can cause mild drowsiness particularly at higher doses. Antihistamines can worsen urinary retention and glaucoma.

First Generation Antihistamines

Second Generation Antihistamines

Cost and Coupons - Desloratadine

Reviews for Desloratadine

Learn more about Desloratadine

Latest research - Desloratadine

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Desloratadine is a stub. If you are familiar with the topic Desloratadine, you can help us. Paid editors welcome!

 

Desloratadine is part of WikiMD's free ^articles!

^Desloratadine (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available