Diazepam (Intravenous)

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Information about Diazepam (Intravenous)

Diazepam is a benzodiazepine that is widely used orally as an anxiolytic agent and muscle relaxant. 

Liver safety of Diazepam (Intravenous)

Intravenous forms of diazepam are used for acute severe agitation, as a premediation for anesthesia, a sedative for minor surgery or invasive procedures, and for treatment of status epileptus or severe recurrent seizures.  Diazepam therapy has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from diazepam has been reported, but is exceedingly rare.

Mechanism of action of Diazepam (Intravenous)

Diazepam (dye az' e pam) is a benzodiazepine that in oral formulations is used for the therapy of anxiety, alcohol withdrawal symptoms and muscle spasms.  Parenteral forms of diazepam are used for control of seizures and status epilepticus and as an adjunct to anesthesia or sedation for minor surgical procedures.  The sedative activity of the benzodiazepines is mediated by their ability to enhance gamma-aminobutyric acid (GABA) mediated inhibition of synaptic transmission through binding to the GABA-A receptor. 

FDA approval information for Diazepam (Intravenous)

Diazepam was approved in the United States in 1963 and is still in wide use with more than 13 million prescriptions filled yearly.  Diazepam is available in tablets of 2, 5 and 10 mg in generic forms and under the brand name of Valium.  Oral solutions and rectal gels are also available.  Current indications for oral diazepam include treatment of anxiety disorders, acute alcohol withdrawal and as an adjunct to relief of skeletal muscle spasm.  Among oral forms of benzodiazepines, diazepam is not as effective or well tolerated as a therapy for epilepsy as are clobazam, clonazepam and clorazepate.  The typical dose of diazepam used for anxiety is 2 to 10 mg given two to four times daily.  Diazepam is also available as a solution for injection, usually in vials or syringes of 5 mg/mL.  Current indications for intravenous diazepam include premedication for surgery, acute agitation due to alcohol withdrawal, as an adjunct to endoscopic and minimally invasive procedures and for treatment of status epilepticus and severe recurrent seizures.  Common side effects of diazepam include somnolence, dizziness, confusion, dysarthria, and diplopia. Acute overdose of diazepam can cause coma, respiratory arrest and death.

Benzodiazipines

Anticonvulsants Drugs

Drug class for Diazepam (Intravenous)

Anticonvulsants, and Benzodiazepines]
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