Diazepam (Oral)

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Information about Diazepam (Oral)

Diazepam is a benzodiazepine that is widely used orally as an anxiolytic agent and muscle relaxant.  Intravenous forms of diazepam are used for acute severe agitation, as a premediation for anesthesia, a sedative for minor surgery or invasive procedures, and for treatment of status epileptus or severe recurrent seizures.  Diazepam therapy has not been associated with serum aminotransferase elevations, and clinically apparent liver injury from diazepam has been reported, but is exceedingly rare.

Liver safety of Diazepam (Oral)

Mechanism of action of Diazepam (Oral)

Diazepam (dye az' e pam) is a benzodiazepine that in oral formulations is used for the therapy of anxiety, alcohol withdrawal symptoms and muscle spasms.  Parenteral forms of diazepam are used for control of seizures and status epilepticus and as an adjunct to anesthesia or sedation for minor surgical procedures.  The sedative activity of the benzodiazepines is mediated by their ability to enhance gamma-aminobutyric acid (GABA) mediated inhibition of synaptic transmission through binding to the GABA-A receptor. 

FDA approval information for Diazepam (Oral)

Diazepam was approved in the United States in 1963 and is still in wide use with more than 13 million prescriptions filled yearly. 

Dosage and administration for Diazepam (Oral)

Diazepam is available in tablets of 2, 5 and 10 mg in generic forms and under the brand name of Valium.  Oral solutions and rectal gels are also available.  Current indications for oral diazepam include treatment of anxiety disorders, acute alcohol withdrawal and as an adjunct to relief of skeletal muscle spasm.  Among oral forms of benzodiazepines, diazepam is not as effective or well tolerated as a therapy for epilepsy as are clobazam, clonazepam and clorazepate.  The typical dose of diazepam used for anxiety is 2 to 10 mg given two to four times daily.  Diazepam is also available as a solution for injection, usually in vials or syringes of 5 mg/mL. 

Clinical use of Diazepam (Oral)

Current indications for intravenous diazepam include premedication for surgery, acute agitation due to alcohol withdrawal, as an adjunct to endoscopic and minimally invasive procedures and for treatment of status epilepticus and severe recurrent seizures.  Common side effects of diazepam include somnolence, dizziness, confusion, dysarthria, and diplopia. Acute overdose of diazepam can cause coma, respiratory arrest and death.

Benzodiazipines

Anticonvulsants Drugs

Drug class for Diazepam (Oral)

Anticonvulsants, and Benzodiazepines]
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Information about Diazepam (Oral)

Diazepam is a benzodiazepine that is available for both oral and intravenous administration; oral diazepam is used predominantly as an anxiolytic agent, while the intravenous form is used as an anticonvulsant. 

Liver safety of Diazepam (Oral)

Use of intravenous diazepam has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. In contrast, use of the oral form of diazepam has been linked to rare instances of cholestatic liver injury.  

Mechanism of action of Diazepam (Oral)

Diazepam (dye az' e pam) is a benzodiazepine with particularly potent activity against spread of seizure activity in several animal models.  The antiseizure activity of the benzodiazepines is mediated by their ability to enhance gamma-aminobutryic acid (GABA) mediated inhibition of synaptic transmission through binding to the GABA A receptor.  The use of diazepam as an anticonvulsant is limited largely to intravenous therapy of status epilepticus.  Oral diazepam is not as effective or well tolerated as a therapy for epilepsy as are other benzodiazepines such as clobazam, clonazepam and clorazepate. 

FDA approval information for Diazepam (Oral)

Diazepam was approved in the United States in 1963 and it is currently widely used to treat acute seizures and status epilepticus.  Indications also include premedication before surgical operations and as conscious sedation for minor invasive procedures.  Several generic forms of parenteral diazepam are available in ampules of 5 mg/mL. 

Dosage and administration for Diazepam (Oral)

The typical recommended dose for status epilepticus is 5 to 10 mg given intravenously, which can be repeated at 10 to 15 minute intervals until control of seizure activity or to a maximum of 30 mg.  Intramuscular administration can be used for premedication before general anesthesia. 

Side effects of Diazepam (Oral)

Common effects of the use of parenteral diazepam include somnolence, confusion, dysarthria, diplopia and coma. Acute overdose of diazepam can cause respiratory arrest and death.

Benzodiazipines

Anticonvulsants Drugs

Drug class for Diazepam (Oral)

Anticonvulsants, and Benzodiazepines]
The article on Diazepam (Oral) is a stub. YOU can help Wikimd by expanding it!

Medication resources

Learn more


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About WikiMD

About us: WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Our mission: Provide up to date physician reviewed health, nutrition and wellness information for free in over 100 languages.

Join us: This article is a stub. Help improve Diazepam (Oral) or others. Do not trust amateurs with your life! Join us in this effort!. Paid editors welcome.

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