Differentiation Syndrome

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Differentiation Syndrome
TermDifferentiation Syndrome
Short definitionDifferentiation Syndrome - (pronounced) (DIH-feh-REN-shee-AY-shun SIN-drome) serious side effect that can occur in patients with acute promyelocytic leukemia or other types of acute myeloid leukemia who have been treated with certain types of anticancer medicines. Differentiation syndrome usually occurs within 1 to 2 weeks of starting treatment, but can occur later. 
TypeCancer terms
SpecialtyOncology
LanguageEnglish
SourceNCI
Comments


Differentiation Syndrome - (pronounced) (DIH-feh-REN-shee-AY-shun SIN-drome) serious side effect that can occur in patients with acute promyelocytic leukemia or other types of acute myeloid leukemia who have been treated with certain types of anticancer medicines. Differentiation syndrome usually occurs within 1 to 2 weeks of starting treatment, but can occur later. It is caused by a large, rapid release of cytokines (immune substances) from leukemia cells affected by the cancer drugs. Signs and symptoms of differentiation syndrome include fever; to cough; difficulty breathing; weight gain; swelling of the arms, legs and neck; accumulation of excess fluid around the heart and lungs; low blood pressure; and kidney failure. Differentiation syndrome can be life-threatening if not treated early

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