Diphenylpyraline
Diphenylpyraline (pronunciation: di-fen-il-pi-ra-leen) is a first-generation antihistamine belonging to the ethanolamine class of antihistamines, which also includes carbinoxamine, clemastine, and doxylamine. It was first synthesized and patented in the 1940s by Janssen Pharmaceutica, a pharmaceutical company based in Belgium.
Etymology
The term "Diphenylpyraline" is derived from its chemical structure, which consists of two phenyl groups attached to a pyrrolidine ring.
Pharmacology
Diphenylpyraline is a H1 receptor antagonist, which means it works by blocking the action of histamine at the H1 receptor, thereby preventing the symptoms of allergies. It is also known to have anticholinergic effects, which can lead to side effects such as dry mouth and constipation.
Clinical Use
Diphenylpyraline is used for the treatment of allergic rhinitis, urticaria, and other allergic reactions. It can also be used as a sedative due to its calming effects.
Side Effects
Common side effects of Diphenylpyraline include drowsiness, dry mouth, blurred vision, and constipation. In rare cases, it can cause tachycardia, difficulty urinating, and confusion.
Related Terms
External links
- Medical encyclopedia article on Diphenylpyraline
- Wikipedia's article - Diphenylpyraline
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