Disulfide bridge
Disulfide Bridge
Disulfide Bridge (pronunciation: /dɪˈsʌlfaɪd brɪdʒ/) is a covalent bond that is formed between two Cysteine residues in a Protein molecule.
Etymology
The term "Disulfide Bridge" is derived from the presence of two sulfur atoms in the bond, hence the prefix 'di-', and the bridge-like structure that it forms between two cysteine residues in a protein molecule.
Definition
A Disulfide Bridge is a strong covalent bond formed between the sulfur atoms of two cysteine residues in a protein molecule. This bond plays a crucial role in the folding and stability of proteins, particularly those secreted from cells. The formation and breakage of disulfide bridges can lead to significant changes in a protein's structure and function.
Related Terms
- Cysteine: An amino acid that contains a thiol group, which can form a disulfide bridge with another cysteine residue.
- Protein: A large molecule composed of one or more chains of amino acids in a specific order.
- Covalent Bond: A type of chemical bond where two atoms share a pair of electrons.
- Protein Folding: The process by which a protein structure assumes its functional shape or conformation.
- Protein Stability: The ability of a protein to maintain its three-dimensional structure under various physiological and environmental conditions.
External links
- Medical encyclopedia article on Disulfide bridge
- Wikipedia's article - Disulfide bridge
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