Doravirine

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Doravirine (pronounced: dora-vi-rine) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV (Human Immunodeficiency Virus). It is marketed under the brand name Pifeltro and is also available in combination with lamivudine and tenofovir disoproxil fumarate in a product called Delstrigo.

Etymology

The name "Doravirine" is derived from the class of drugs it belongs to, non-nucleoside reverse transcriptase inhibitors (NNRTIs). The prefix "Dora-" is arbitrary and does not have a specific meaning, while "-virine" is a common suffix for NNRTIs, indicating its function in inhibiting the reverse transcriptase enzyme.

Usage

Doravirine is used in combination with other antiretroviral medications to treat HIV-1 infection in adults who have not previously received antiretroviral therapy or who are replacing their current antiretroviral regimen. It works by blocking the action of reverse transcriptase, an enzyme that the virus needs to multiply.

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