Dose response relationship
Dose-Response Relationship
The Dose-Response Relationship (pronunciation: /doʊs-rɪˈspɒns rɪˈleɪʃənʃɪp/) is a fundamental concept in Pharmacology and Toxicology, describing the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a chemical) after a certain exposure time.
Etymology
The term "Dose-Response Relationship" is derived from the fields of Pharmacology and Toxicology. "Dose" refers to the quantity of a substance that may be absorbed by a living organism, while "Response" refers to the reaction or change in the organism due to the dose. "Relationship" in this context refers to the correlation between the dose and the response.
Definition
In a Dose-Response Relationship, the magnitude of the response of an organism is functionally related to the amount of dose received. This relationship is used to assess the risk of Toxicity and the efficacy of drugs. The relationship can be divided into two types: graded dose-response (which measures the response in a single individual) and quantal dose-response (which measures the response in a population).
Related Terms
See Also
External links
- Medical encyclopedia article on Dose response relationship
- Wikipedia's article - Dose response relationship
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