Information about Dutasteride
Dutasteride is a 5-alpha reductase inhibitor used in the therapy of symptomatic benign prostatic hypertrophy.
Liver safety of Dutasteride
Dutasteride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent acute liver injury.
Mechanism of action of Dutasteride
Dutasteride (doo tas' ter ide) was the second 5-alpha reductase inhibitor to be approved in the United States for the treatment of symptomatic benign prostatic hypertrophy. Dutasteride inhibits the conversion of testosterone to dihydrotestosterone, which is important in the development and maintenance of prostatic hyperplasia. Dihydrotesterone levels decrease during dutasteride therapy, but serum testosterone levels do not. Dutasteride usually takes several months to have an effect on prostate size and the symptoms of prostatic hypertrophy (urinary hesitancy and poor stream), unlike the alpha-1 adrenergic receptor blockers (alpha blockers) which have a more immediate effect.
FDA approval information for Dutasteride
Dutasteride was approved for use in the United States in 2001 and is available in 0.5 mg capsules generically and under the trade name Avodart. A fixed dose combination of dutasteride (0.5 mg) with tamsulosin (0.4 mg: an alpha blocker) is available under the trade name Jalyn. The recommended dose of dutasteride is 0.5 mg once daily. Dutasteride is usually given long term and an effect is usually not seen until 3 to 6 months of therapy.
Side effects of Dutasteride
Side effects are uncommon, but include impotence and decreased libido, ejaculation disorders, gynecomastia, dizziness and fatigue. Dutasteride also decreases serum PSA levels which should be monitored during therapy. Alpha-blockers used to treat benign prostatic hypertrophy (BPH):
5-Alpha Reductase Inhibitors
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