From WikiMD
Jump to navigation Jump to search
Other languages:

Information about Dutasteride

Dutasteride is a 5-alpha reductase inhibitor used in the therapy of symptomatic benign prostatic hypertrophy.

Liver safety of Dutasteride

Dutasteride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent acute liver injury.

Mechanism of action of Dutasteride

Dutasteride (doo tas' ter ide) was the second 5-alpha reductase inhibitor to be approved in the United States for the treatment of symptomatic benign prostatic hypertrophy. Dutasteride inhibits the conversion of testosterone to dihydrotestosterone, which is important in the development and maintenance of prostatic hyperplasia. Dihydrotesterone levels decrease during dutasteride therapy, but serum testosterone levels do not. Dutasteride usually takes several months to have an effect on prostate size and the symptoms of prostatic hypertrophy (urinary hesitancy and poor stream), unlike the alpha-1 adrenergic receptor blockers (alpha blockers) which have a more immediate effect.

FDA approval information for Dutasteride

Dutasteride was approved for use in the United States in 2001 and is available in 0.5 mg capsules generically and under the trade name Avodart. A fixed dose combination of dutasteride (0.5 mg) with tamsulosin (0.4 mg: an alpha blocker) is available under the trade name Jalyn. The recommended dose of dutasteride is 0.5 mg once daily. Dutasteride is usually given long term and an effect is usually not seen until 3 to 6 months of therapy.

Side effects of Dutasteride

Side effects are uncommon, but include impotence and decreased libido, ejaculation disorders, gynecomastia, dizziness and fatigue. Dutasteride also decreases serum PSA levels which should be monitored during therapy. Alpha-blockers used to treat benign prostatic hypertrophy (BPH):

5-Alpha Reductase Inhibitors

Cost and Coupons - Dutasteride

Reviews for Dutasteride

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Articles on Dutasteride

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Dutasteride

Drug classes

WikiMD resources 360 on Dutasteride - scientific articles to social media


Policies / Guidelines Social Media


Patient Resources / Community
Facebook posts

Evidence Based Medicine

Healthcare Provider Resources
YouTube videos

Clinical Trials

External:W8MD Weight Loss, Sleep & MedSpa Wellness Topics A-Z Other resources

A | B | C | D | E | F | G

H | I | J | K | L | M | N

O | P | Q | R | S | T | U

V | W | X | Y | Z

Ad. Tired of being overweight? W8MD's insurance weight loss* program can HELP | Advertise on WikiMD

Other languages:

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary.