Ecallantide
Ecallantide (pronounced as e-kal-lan-tide) is a protein used in the treatment of hereditary angioedema, a rare genetic disorder. It is a recombinant protein that functions as a kallikrein inhibitor, preventing the release of bradykinin, a peptide that causes blood vessels to dilate and become permeable.
Etymology
The name "Ecallantide" is derived from the words "ecall" and "antide". "Ecall" is a reference to the drug's function as an inhibitor of kallikrein, and "antide" is a common suffix used in the names of drugs that act as antagonists or inhibitors.
Usage
Ecallantide is used to treat acute attacks of hereditary angioedema in patients 12 years of age and older. It is administered subcutaneously, usually in a healthcare setting due to the risk of anaphylaxis.
Mechanism of Action
Ecallantide inhibits the protein kallikrein, which is involved in the production of bradykinin. By inhibiting kallikrein, ecallantide prevents the release of bradykinin, thereby reducing the symptoms of hereditary angioedema, such as swelling and pain.
Related Terms
See Also
External links
- Medical encyclopedia article on Ecallantide
- Wikipedia's article - Ecallantide
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