Epoxomicin
Epoxomicin
Epoxomicin (pronounced: eh-pox-oh-mi-sin) is a naturally occurring selective proteasome inhibitor with potential anti-inflammatory and antineoplastic activities.
Etymology
The term "Epoxomicin" is derived from the Greek words "epo" meaning upon, "xomi" meaning heap, and "cin" meaning movement. This refers to the compound's ability to act upon protein heaps or aggregates in the cell, inhibiting their movement or degradation.
Definition
Epoxomicin is a potent, selective, and irreversible inhibitor of the proteasome, a large protein complex responsible for the degradation of intracellular proteins. It was originally isolated from the actinomycete strain Q996-17. Epoxomicin specifically inhibits the chymotrypsin-like activity of the 20S proteasome and selectively induces apoptosis in transformed cells.
Medical Uses
Epoxomicin has been used in the study of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. It has been shown to inhibit the growth of tumor cells in vitro and in vivo, and to protect neurons from apoptosis in models of neurodegenerative diseases.
Related Terms
See Also
External links
- Medical encyclopedia article on Epoxomicin
- Wikipedia's article - Epoxomicin
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