COVID-19 transmission graph

Coronavirus: WHO declares COVID 19 a pandemic. Prevention | FAQs | COVID-19 portal

URGENT:COVID prophylaxis | Vitamin D | Latest research | NIH | CDC | Worldometer

NB:Did you know one coronavirus patient can infect 59,000 others if nothing is done? Dietary cholesterol may not raise cardiovascular risk! Ketogenic diet

Eribulin

From WikiMD
Jump to navigation Jump to search

Information about Eribulin

Eribulin mesylate is an inhibitor of microtubule function and is used as an antineoplastic agent for refractory, metastatic breast cancer and liposarcoma. 

Liver safety of Eribulin

Despite its cytotoxic activity against cancer cells, eribulin has rarely been implicated in causing clinically apparent acute liver injury

Mechanism of action of Eribulin

Eribulin (er' i bue' lin) is a synthetic macrocyclic analogue of halichondrin B, a naturally occurring inhibitor of mitotic division found in a species of marine sponges (Halichondria okadai).  Eribulin binds to the growing ends of microtubules preventing cell division (mitotic arrest) which leads to tubulin sequestration in aggregates and apoptotic cell death. 

FDA approval information for Eribulin

Eribulin was approved for use in cancer chemotherapy in 2010 and current indications are for metastatic breast cancer after failure of chemotherapy with an anthracycline and taxane.  It is also approved for use in metastatic, refractory liposarcoma.  Eribulin is given intravenously in doses of 1.4 mg/m2, typically on days 1 and 8 of 21 day cycles.  Eribulin is available in single use vials of 1 mg per 2 mL under the trade name Halaven. 

Side effects of Eribulin

Side effects are common and include nausea, vomiting, fatigue, headache, dizziness, peripheral neuropathy, hoarseness, ataxia, dysphagia, urinary retention, constipation, diarrhea, bone marrow suppression, alopecia and phlebitis at the infusion site.  Rare, but potentially severe adverse events include severe neutropenia, peripheral neuropathy, prolongation of the QTc interval and embryo-fetal toxicity.

 


The article on Eribulin is a stub. YOU can help Wikimd by expanding it!

Medication resources

Learn more

Apple bitten.svg

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Help WikiMD: Find something you can improve? Join WikiMD as an an editor and help improve the page Eribulin or others.

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Eribulin">Eribulin</a>

  • Individual results may vary for weight loss from our sponsors.