Wikimd logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
14,007 pages, 4,159,090 edits & 43,392,504 views.

Free unbiased diet, health and wellness info!

Eribulin

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Eribulin

Eribulin mesylate is an inhibitor of microtubule function and is used as an antineoplastic agent for refractory, metastatic breast cancer and liposarcoma. 

Eribulin
Eribulin

Liver safety of Eribulin

Despite its cytotoxic activity against cancer cells, eribulin has rarely been implicated in causing clinically apparent acute liver injury

Mechanism of action of Eribulin

Eribulin (er' i bue' lin) is a synthetic macrocyclic analogue of halichondrin B, a naturally occurring inhibitor of mitotic division found in a species of marine sponges (Halichondria okadai).  Eribulin binds to the growing ends of microtubules preventing cell division (mitotic arrest) which leads to tubulin sequestration in aggregates and apoptotic cell death. 

FDA approval information for Eribulin

Eribulin was approved for use in cancer chemotherapy in 2010 and current indications are for metastatic breast cancer after failure of chemotherapy with an anthracycline and taxane.  It is also approved for use in metastatic, refractory liposarcoma.  Eribulin is given intravenously in doses of 1.4 mg/m2, typically on days 1 and 8 of 21 day cycles.  Eribulin is available in single use vials of 1 mg per 2 mL under the trade name Halaven. 

Side effects of Eribulin

Side effects are common and include nausea, vomiting, fatigue, headache, dizziness, peripheral neuropathy, hoarseness, ataxia, dysphagia, urinary retention, constipation, diarrhea, bone marrow suppression, alopecia and phlebitis at the infusion site.  Rare, but potentially severe adverse events include severe neutropenia, peripheral neuropathy, prolongation of the QTc interval and embryo-fetal toxicity.

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

 

Cost and Coupons - Eribulin

Reviews for Eribulin

Learn more about Eribulin

Latest research - Eribulin

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Eribulin is a stub. If you are familiar with the topic Eribulin, you can help us. Paid editors welcome!

 

Eribulin is part of WikiMD's free ^articles!

^Eribulin (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available