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Information about Estazolam

Estazolam is an orally available benzodiazepine used to treat insomnia

Liver safety of Estazolam

As with most benzodiazepines, estazolam therapy has not associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from estazolam has not been reported and must be very rare, if it occurs at all.  

Mechanism of action of Estazolam

Estazolam (es taz' oh lam) is a benzodiazepine used as a sleeping aid in the therapy of insomnia.  The antianxiety (anxiolytic) and soporific activity of the benzodiazepines is mediated by their ability to enhance gamma-aminobutyric acid (GABA) mediated inhibition of synaptic transmission through binding to the GABA A receptor. 

FDA approval information for Estazolam

Estazolam was approved in the United States in 1990 for the short term management of insomnia

Dosage and administration for Estazolam

Estazolam is available in tablets of 1 and 2 mg in several generic forms and formerly under the brand name ProSom.  The recommended initial oral dose for adults is 1 mg at bedtime, which can be increased to 2 mg nightly, but is not recommended as chronic therapy. 

Side effects of Estazolam

The most common side effects of estazolam are dose related and include daytime drowsiness, lethargy, ataxia, dysarthria and dizziness.  Tolerance develops to these side effects, but tolerance may also develop to the effects on insomnia.


Anticonvulsants Drugs

Drug class for Estazolam

Anticonvulsants, and Benzodiazepines]
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