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Information about Exenatide

Exenatide is an analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents.

Liver safety of Exenatide

There have been no published reports of hepatotoxicity attributed to exenatide therapy.

Mechanism of action of Exenatide

Exenatide (ex en' a tide) is a synthetic analogue of glucagon-like peptide-1 (GLP-1) that acts like the native gastrointestinal hormone (incretin) to increase insulin secretion. Exenatide, like GLP-1, increases insulin secretion by the pancreas and can improve glycemic control in patients with type 2 diabetes. Exenatide is a polypeptide initially extracted from salivary glands of the Gila monster and has close homology (53%) to human GLP-1, but is resistant to DPP-4 degradation and thus has a prolonged duration of activity. Exenatide (also known as exendin-4) must be given parenterally. Exenatide

FDA approval information for Exenatide

Exenatide was approved for use in the United States in 2005, and current indications are for the management of glycemic control in adults with type 2 diabetes used in combination with diet and exercise, with or without other oral hypoglycemic agents.

Brand name for Exenatide

Exenatide is available under the brand name Byetta in solution for subcutaneous injection in prefilled pens of 5 or 10 mcg.

Dosage and administration for Exenatide

The typical dose is 5 to 10 mcg twice daily. A long acting form has recently become available under the name Bydureon, which is given subcutaneously in doses of 2 mg once weekly.

Side effects of Exenatide

Exenatide is generally well tolerated, but side effects can include nausea, diarrhea, dizziness, headache, fatigue and rash.


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