Wikimd logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
15,664 pages, 4,131,648 edits & 37,585,730 views.

Free unbiased diet, health and wellness info!

Ezetimibe

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search
Other languages:
English

Information about Ezetimibe

Ezetimibe is an inhibitor of intestinal cholesterol absorption that is widely used in the therapy of hypercholesterolemia, usually in combination with other agents. Ezetimibe therapy is associated with a low rate of serum aminotransferase elevations and clinically apparent liver injury due to ezetimibe occurs, but is rare.

Mechanism of action of Ezetimibe

Ezetimibe (e zet' i mibe) is a synthetic azetidinone that inhibits cholesterol absorption from the intestine. Ezetimibe acts by binding to and inhibiting the Niemann-Pick C1-like 1 protein (NPC1), the major transporter of cholesterol in the intestinal brush border. Ezetimibe by itself lowers serum cholesterol, but the inhibition of cholesterol absorption is usually followed by a compensatory increase in hepatic cholesterol synthesis, a response that can be blocked by hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors [statins]. For this reason, ezetimibe is commonly used in combination with a statin. Addition of ezetimibe to a maximized dose of statins generally lowers LDL-cholesterol levels by 22% to 24%.

FDA approval information for Ezetimibe

Ezetimibe was approved for use in the United States in 2002 and is usually recommended as an adjunctive therapy to diet or in combination with a statin in management of patients with hypercholesterolemia at high risk for cardiovascular or cerebrovascular disease. It is also used alone in patients who are intolerant of statins and can be combined with other lipid-lowering agents (such as fibrates or anti-PCSK9 monoclonal antibodies).

Dosage and administration for Ezetimibe

Ezetimibe is available in 10 mg tablets under the brand name Zetia and the usually recommended dose is 10 mg daily. Ezetimibe is also available in a fixed combination with simvastatin (20 or 40 mg) under the trade name Vytorin and with atorvastatin (10, 20, 40 or 80 mg) under the trade name Liptruzet. Ezetimibe has achieved wide scale acceptance and several million prescriptions are filled yearly.

Side effects of Ezetimibe

Common side effects of ezetimibe include diarrhea and flatulence. Rare, potentially severe adverse effects include hypersensitivity reactions, myopathy and rhabdomyolysis.

Lipid lowering medications

Cost and Coupons - Ezetimibe

Reviews for Ezetimibe

Learn more about Ezetimibe

Latest research - Ezetimibe

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Ezetimibe is a stub. If you are familiar with the topic Ezetimibe, you can help us. Paid editors welcome!

 

Ezetimibe is part of WikiMD's free ^articles!

^Ezetimibe (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available

Other languages:
English