Factor V deficiency
Factor V Deficiency
Factor V deficiency (pronounced: "factor five deficiency"), also known as Owren's disease or parahemophilia, is a rare coagulation disorder characterized by a deficiency or dysfunction of Factor V, an essential protein involved in blood clotting.
Etymology
The term "Factor V" is derived from the Roman numeral for 5, as it was the fifth clotting factor to be discovered. The term "deficiency" refers to the lack or shortage of something. The term "Owren's disease" is named after Paul Owren, a Norwegian physician who first described the condition in 1947. The term "parahemophilia" is derived from the Greek words "para" meaning "beside" or "beyond", and "hemophilia" meaning "love of blood", indicating a condition similar to, but distinct from, hemophilia.
Symptoms
Symptoms of Factor V deficiency can vary widely, from mild to severe, and may include easy bruising, nosebleeds, gum bleeding, menorrhagia (heavy menstrual bleeding), and hemarthrosis (bleeding into joint spaces). Severe cases can lead to life-threatening bleeding disorders such as hemorrhage.
Diagnosis
Diagnosis of Factor V deficiency typically involves blood tests to measure the level of Factor V in the blood. These may include a prothrombin time (PT) test, an activated partial thromboplastin time (aPTT) test, and a Factor V assay.
Treatment
Treatment for Factor V deficiency may involve blood transfusions to replace the missing Factor V, or the use of antifibrinolytic drugs to help prevent excessive bleeding. In some cases, recombinant Factor V may be used.
Related Terms
External links
- Medical encyclopedia article on Factor V deficiency
- Wikipedia's article - Factor V deficiency
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