Factor XIII
Factor XIII
Factor XIII (pronounced as "Factor Thirteen"), also known as Fibrin Stabilizing Factor (FSF), is a enzyme that plays a crucial role in the blood coagulation process.
Pronunciation
Factor XIII: /ˈfæk.tər θɜːrˈtiːn/
Etymology
The term "Factor XIII" is derived from the sequential numbering of the blood clotting factors discovered. The Roman numeral XIII signifies that it was the thirteenth clotting factor to be identified.
Function
Factor XIII is activated by thrombin in the presence of calcium ions to become Factor XIIIa. Factor XIIIa is an transglutaminase that catalyzes the formation of covalent bonds between fibrin molecules, stabilizing the fibrin clot.
Related Terms
- Coagulation: The process by which blood changes from a liquid to a gel, forming a clot.
- Thrombin: An enzyme in blood plasma that causes the clotting of blood by converting fibrinogen to fibrin.
- Fibrin: A fibrous protein involved in the clotting of blood.
- Transglutaminase: An enzyme that catalyzes the formation of an isopeptide bond between a free amine group and the acyl group at the end of the side chain of protein- or peptide-bound glutamine.
Disorders
Deficiency of Factor XIII, known as Factor XIII deficiency, is a rare genetic disorder characterized by abnormal blood clotting that can lead to excessive bleeding.
Treatment
Treatment for Factor XIII deficiency typically involves regular infusions of Factor XIII concentrate to replace the missing or malfunctioning Factor XIII.
External links
- Medical encyclopedia article on Factor XIII
- Wikipedia's article - Factor XIII
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