Fibronectin
Fibronectin
Fibronectin (pronounced: fy-bro-nek-tin) is a high-molecular weight (~440kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).
Etymology
The term "Fibronectin" is derived from the words "Fibro-", which refers to fibrous tissues, and "-nectin", which is derived from the Latin word "nectere", meaning "to bind".
Function
Fibronectin plays a crucial role in cell adhesion, growth, migration, and differentiation, and it is important for processes such as wound healing and embryonic development.
Related Terms
- Integrins: A family of cell surface proteins that interact with the extracellular matrix and mediate various intracellular signals. They allow cells to engage with their surroundings in a dynamic manner.
- Collagen: The most abundant protein in the body, forming strong sheets and cables that support the structure of the skin, internal organs, and connective tissues.
- Fibrin: A protein involved in the clotting of blood, it is formed by the action of the protease thrombin on fibrinogen which causes it to polymerize.
- Heparan Sulfate Proteoglycans: These are proteins with one or more covalently attached glycosaminoglycan chain(s). They are present on the surface of all animal cells and influence a host of biological phenomena.
External links
- Medical encyclopedia article on Fibronectin
- Wikipedia's article - Fibronectin
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