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Fidaxomicin
Information about Fidaxomicin
Fidaxomicin is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults.
Liver safety of Fidaxomicin
Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent, acute liver injury.
Mechanism of action of Fidaxomicin
Fidaxomicin (fye dax" oh mye' sin) is a semisynthetic macrolide antibiotic that is minimally absorbed and has potent bactericidal activity against Clostridia, but minimal or no antibacterial activity against normal gastrointestinal flora.
FDA approval information for Fidaxomicin
Because of its lack of oral absorption and restricted antibacterial activity, fidaxomicin was developed as an oral therapy for Clostridium difficile and was approved for this use in the United States in 2011.
Dosage and administration for Fidaxomicin
Fidaxomicin is available in tablets of 200 mg under the brand name Dificid. The typical regimen is 200 mg twice daily for 10 days which is effective in eradicating C. difficile in 80% to 90% of patients.
Side effects of Fidaxomicin
Fidaxomicin is generally well tolerated, but side effects can include nausea, vomiting, abdominal pain, diarrhea, dyspepsia, headache, gastrointestinal hemorrhage, anemia and neutropenia. Rare, but potentially severe adverse events include hypersensitivity reactions (rash, angioedema) and drug resistant bacterial infection.
The following are macrolides
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