File:Overview of diverse HCMV proteome involved in modulation of host cell controlled growth.jpg
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Summary
| Description |
日本語: UL76 ウイルス蛋白は、染色体の変異（chromosomal aberrations）を誘導する。
IE1 ウイルス蛋白は、テロメラーゼ活性（telomerase activity）を上げる。 IE1・IE2・pUL36・pUL37・pUL38 ウイルス蛋白は、アポトーシスを阻害するウイルス蛋白（anti-apoptotic proteins）で、腫瘍細胞の不死化を亢進させる。 IE1・pUL16・pUL18・pUS11・pp65・pp71 ウイルス蛋白は、免疫機構からの逃避（immune escape）に関わり、腫瘍免疫への抵抗性を上げる。 IE1・IE2・US28 ウイルス蛋白は、癌遺伝子として働くと推察される蛋白（putative oncogenes）。 IE1・IE2・US28・pUL97・pp65 ウイルス蛋白は、癌抑制遺伝子のカウンター蛋白質（viral counter proteins against tumor suppresors）であり、発癌の抑制を阻害する。 |
| Date | |
| Source | Herbein G, Kumar A (2014). "The oncogenic potential of human cytomegalovirus and breast cancer". Frontiers of Oncology. 4: 230. PMCID: PMC4142708. PMID: 25202681. doi: 10.3389/fonc.2014.00230. |
| Author | Georges Herbein, Amit Kumar |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 13:47, 27 July 2018 | | 992 × 771 (297 KB) | wikimediacommons>圧倒的暇人の極み | User created page with UploadWizard |
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