Flavocoxid

Information about Flavocoxid

Flavocoxid is a medical food consisting of plant derived flavonoids which have antiinflammatory activity and are used to treat chronic osteoarthritis.

Liver safety of Flavocoxid

Flavocoxid has been linked to minor elevations in serum enzyme levels during therapy and to rare instances of clinically apparent liver injury.

Mechanism of action of Flavocoxid

Flavocoxid (flay" voe kox' id) is a proprietary blend of purified plant derived bioflavonoids including baicalin and catechins. Flavocoxid inhibits cyclooxygenases (both Cox-1 and Cox-2) as well as lipoxygenases (5-Lox) in vitro and in animal models, which may account for its antiinflammatory and antioxidant activity. Flavocoxid inhibits the conversion of arachidonic acid to reactive prostaglandins and reduces the levels of these inflammatory mediators in synovial fluid.

FDA approval information for Flavocoxid

Flavocoxid was approved for use as a medical food in the United States in 2004.

The drug Flavocoxid was withdrawn from the US market

However, this approval was withdrawn in December 2017 and it is not longer available as an FDA approved medical food. It was previously available by prescription for use in chronic osteoarthritis in tablets of 500 mg under the commercial name Limbrel.

Dosage and administration for Flavocoxid

The typical dose was 500 mg twice daily.

Side effects of Flavocoxid

Side effects were not common and were similar in frequency to those experienced by patients on placebo.

Antirheumatic Agents

• Gold Preparations

• • Auranofin, Gold salts, Gold sodium thiomalate

• Interleukin receptor antagonists

• • Anakinira, Canakinumab, Rilonacept, Sarilumab, Tocilizumab

• Major immunosuppressive agents

• • Cyclosporine, Mycophenylate, Sirolimus, Tacrolimus

• Monoclonal antibodies

• • Adalimumab, Canakinumab, Certolizumab, Golimumab, Infliximab, Rituximab, Sarilumab, Tocilizumab, Ustekinumab

• Thiopurines

• • Azathioprine, Mercaptopurine, Thioguanine

• Tumor necrosis factor antagonists

• • Adalimumab, Certolizumab, Etanercept, Golimumab, Infliximab

• Tyrosine kinase inhibitors

• • Baricitinib, Tofacitinib

• Miscellaneous

• • Abatacept, Flavocoxid, Hydroxychloroquine, Leflunomide, Methotrexate, Penicillamine

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