Fluoxymesterone

From WikiMD

Fluoxymesterone is a medication that acts similarly to male sex hormones.

Information about Fluoxymesterone

Androgenic steroids are used for male sex hormone replacement and in the therapy of malignancies. The androgens also have anabolic effects and are used in catabolic or muscle wasting states. The synthetic anabolic steroids are also widely used illicitly for body building.

Liver safety of Fluoxymesterone

Many synthetic androgenic steroids are capable of causing cholestatic liver injury and long term use of androgens is associated with development of liver tumors including hepatocellular carcinoma and hepatic adenoma.

Mechanism of action of Fluoxymesterone

Modifications of testosterone have been developed that are more bioavailable or have a longer duration of action. Modification by esterification (testosterone cypionate, enanthate and propionate) maintains the virilizing effects of testosterone, but increases potency and duration of action. Alkylation of the C-17 position of testosterone allows for oral administration and often alters the relative anabolic potency in relation to the masculinizing effects. The C-17 alkylated testosterones include methyltestosterone (meth" il tes tos' ter one), methandrostenolone (meth an" droe stene' oh lone), oxymetholone (ox" i meth' oh lone), danazol (dan' a zol), fluoxymesteone (floo ox" i mes' ter one), stanazol (stan oh' zoe lol), norethandrolone (nor eth' an drone) and oxandrolone (ox an' droe lone), and have been extensively evaluated as a means of increasing weight gain and muscle development in catabolic states as well as to improve athletic performance.

Indications (use) - Fluoxymesterone

They have also been used to treat aplastic anemia and bone marrow failure of several causes. They are often well tolerated and have limited virilizing activity. However, the C-17 alkylated androgenic steroids have all been implicated in cases of liver injury, including prolonged cholestasis, peliosis hepatis, nodular regeneration, hepatic adenomas and hepatocellular carcinoma. In contrast, the esterified testosterones have only rarely been implicated in causing cholestasis, although their long term use may increase the risk of hepatic tumors and nodular transformation, but seemingly at a much lower rate than the 17-alkylated testosterones.

Other uses of Fluoxymesterone

Current uses of androgenic steroids include androgen deficiency, breast cancer, postpartum breast engorgement, hereditary angioneurotic edema, endometriosis and fibrocystic breast disease. The androgenic steroids are also used off label and illegally as a means of increasing muscle mass and athletic performance. The abuse of anabolic steroids is particularly common among body builders and young male athletes, although their use has been banned from the Olympics and in major professional and college sports. Recently, anabolic steroids have been found in some nutritional supplements available over-the-counter or via the internet which are advertised as increasing a sense of well being and muscle mass or as an aid to body building.

Brand name for Fluoxymesterone

REPRESENTATIVE TRADE NAMES

  • Danazol – Generic, Danocrine®
  • Fluoxymesterone – Androxy®
  • Methandienone – Dianabol®
  • Methenolone – Primobolan®
  • Methyltestosterone – Android®, Methitest®, Testred®
  • Nandrolone – Generic, Deca-Durabolin®
  • Norethandrolone – Generic, Nilevar®, Norlutin®
  • Oxandrolone – Generic, Oxandrin®
  • Oxymetholone – Anadrol®
  • Stanozolol – Winstrol®
  • Testosterone – Depo-Testosterone®

Drug class for Fluoxymesterone

Anabolic Steroids

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