Fluphenazine

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Information about Fluphenazine

Fluphenazine is a phenothiazine and antipsychotic agent which is no longer in common use.

Liver safety of Fluphenazine

Fluphenazine can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury.

Mechanism of action of Fluphenazine

Fluphenazine (floo fen' a zeen) is a tricyclic aliphatic phenothiazine which acts by postsynaptic inhibition of dopamine receptors. Fluphenazine has other peripheral and central nervous system effects, producing both alpha adrenergic stimulation and blocking histamine- and serotonin-mediated effects.

FDA approval information for Fluphenazine

Fluphenazine was approved in the United States in 1972 for use in the therapy of acute and chronic psychosis. It was formerly a commonly prescribed antipsychotic medication, but in recent years has been replaced in large part by the atypical antipsychotics, which have fewer extrapyramidal side effects. Fluphenazine is currently used as parentral therapy of psychosis and is available generically in solution for depot injection.

Dosage and administration for Fluphenazine

Fluphenazine was previously available under the brand name Prolixin. The typical maintenance dose in adults in 12.5 to 25 mg im or sc every 3 to 6 weeks.

Side effects of Fluphenazine

Common side effects include drowsiness, dizziness, headache, blurred vision, dry mouth, constipation, tremor, restlessness, muscle spasms and weight gain. Rare but potentially severe adverse effects include suicidal thoughts or behaviors, neuroleptic malignant syndrome and tardive dyskinesia.

Antipsychotic agents

First Generation

Second Generation (Atypicals)


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