Follistatin
Follistatin
Follistatin (pronounced /ˈfɒlɪˌstætɪn/) is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release.
Etymology
The term "Follistatin" is derived from the English word "follicle" and the Latin word "statin", which means inhibitor. The term was first used in 1987 when the protein was discovered.
Function
Follistatin is a binding protein for transforming growth factor-beta superfamily proteins. It has been shown to bind and bioneutralize activity of certain members of the TGF-beta superfamily, notably myostatin and activin, which are involved in the regulation of muscle growth and reproductive functions, respectively.
Clinical Significance
Follistatin has been studied for its role in regulation of muscle growth in mice, with implications for humans. It is also being investigated for its role in fertility, as it is known to regulate the gonadotropin-releasing hormone and thus affect the menstrual cycle.
Related Terms
- Follicle-stimulating hormone
- Transforming growth factor beta superfamily
- Myostatin
- Activin
- Gonadotropin-releasing hormone
External links
- Medical encyclopedia article on Follistatin
- Wikipedia's article - Follistatin
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