FRET
FRET
FRET (pronounced /frɛt/), or Fluorescence Resonance Energy Transfer, is a mechanism describing energy transfer between two light-sensitive molecules (chromophores). The energy transfer can occur when the donor chromophore, initially in its electronic excited state, may transfer energy to an acceptor chromophore through nonradiative dipole–dipole coupling. The efficiency of this energy transfer is inversely proportional to the sixth power of the distance between donor and acceptor, making FRET extremely sensitive to small changes in distance.
Etymology
The term FRET is an acronym for Fluorescence Resonance Energy Transfer. The concept was first introduced by Théophile Förster in 1946, hence it is often referred to as Förster Resonance Energy Transfer instead of Fluorescence Resonance Energy Transfer.
Related Terms
- Chromophore: A molecule (or part of a molecule) which absorbs and emits light in a FRET process.
- Fluorescence: The emission of light by a substance that has absorbed light or other electromagnetic radiation.
- Resonance Energy Transfer: The process by which energy can be transferred from one molecule to another.
- Théophile Förster: The scientist who first described the FRET process.
- Dipole–dipole coupling: The mechanism through which the energy transfer in FRET occurs.
External links
- Medical encyclopedia article on FRET
- Wikipedia's article - FRET
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