Gene knockin
Gene Knockin
Gene knockin (pronounced: /dʒiːn nɒkˈɪn/) is a genetic engineering technique that involves the insertion of a gene into the genome of an organism, typically a mouse, to create a transgenic organism. This technique is used to study the function of the gene and its role in disease.
Etymology
The term "gene knockin" is derived from the English words "gene", referring to the basic physical and functional unit of heredity, and "knockin", which is a colloquial term for inserting or introducing something. The term was first used in the context of genetic engineering in the late 20th century.
Procedure
The process of gene knockin involves the use of recombinant DNA technology. A desired gene is inserted into a specific location in the genome using a vector. This vector is then introduced into the organism's cells, where it integrates into the genome. The organism's cells then express the inserted gene, allowing researchers to study its function.
Applications
Gene knockin is used in various fields of biomedical research, including genetics, oncology, and neuroscience. It is particularly useful for studying the function of genes and their role in disease. For example, it can be used to create mouse models of human diseases, which can then be used to study the disease and develop potential treatments.
Related Terms
- Gene knockout: A technique in which a gene is made inoperative, or "knocked out". This is often used to study the function of the gene by observing the effect of its absence.
- Transgenic organism: An organism that has had a foreign gene inserted into its genome.
- Vector (molecular biology): A DNA molecule used to deliver a gene into a cell.
External links
- Medical encyclopedia article on Gene knockin
- Wikipedia's article - Gene knockin
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski