Gene targeting

From WikiMD.org
Jump to navigation Jump to search

Gene Targeting

Gene targeting (pronunciation: /dʒiːn ˈtɑːrɡɪtɪŋ/) is a genetic technique that uses Homologous recombination to modify an endogenous gene. The method can be used to delete a gene, remove exons, add a gene, or introduce point mutations.

Etymology

The term "gene targeting" is derived from the English words "gene", which comes from the Greek word "genea" meaning generation or race, and "targeting", which means to select as an object of attention or attack.

Process

Gene targeting is a type of genetic modification that involves the alteration of an endogenous gene in a cell to create a mutation. This is achieved by creating a construct where the natural gene can be replaced by the altered gene through homologous recombination. The construct is then inserted into stem cells from an organism. These stem cells are then inserted back into the organism, where they can develop into any type of cell, including germ cells which can pass the mutation on to future generations.

Applications

Gene targeting has been used in research to understand the role of specific genes in health and disease. It is also being explored as a potential method for gene therapy, where it could be used to correct genetic defects.

Related Terms

External links

Esculaap.svg

This WikiMD dictionary article is a stub. You can help make it a full article.


Languages: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski