Information about Greater Celandine
Greater celandine is a botanical extract derived from a plant of the Poppy family that is typically used for the treatment of gastrointestinal disorders and dyspepsia.
Liver safety of Greater Celandine
Celandine has been linked to several instances of clinically apparent liver injury.
Mechanism of action of Greater Celandine
Greater celandine (Chelidonium majus) is a plant of the Poppy family (Papaveraceae) which grows wild in Asia and Europe and has been introduced widely in the United States. Leaf extracts may contain up to 20 alkaloids, including benzophenanthridines, protoberberines and hydroxycinnamic acid derivatives. For centuries, celandine has been used to treat gastrointestinal complaints, dyspepsia and gallbladder disease. The chemical compound responsible for the antispasmotic activity of celandine is unknown. Celandine also acts as a mild sedative and it has been used to treat asthma, bronchitis and whooping cough. In recent years, celandine extracts have been used largely as therapy for dyspepsia and gallbladder disease, but it has also been claimed to be beneficial for skin conditions, asthma and bronchitis and as a weight loss agent. No human studies have been done that substantiate the benefits of celandine in these conditions or to define its safety, tolerability and adverse effects.
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