High-throughput screening
High-throughput screening (HTS) is a method for scientific experimentation especially used in drug discovery and relevant fields of biology and chemistry. Using robotics, data processing and control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests. Through this process one can rapidly identify active compounds, antibodies, or genes which modulate a particular biomolecular pathway. The results of these experiments provide starting points for drug design and for understanding the interaction or role of a particular biochemical process in biology.
Pronunciation
High-throughput screening: /haɪ θruːˈpʊt ˈskriːnɪŋ/
Etymology
The term "high-throughput" refers to the ability to process a large number of cases or data. "Screening" in this context refers to the process of testing or examining something in a methodical manner.
Related Terms
- Biochemical assay: A biochemical assay is a qualitative or quantitative procedure designed to detect, quantify, or identify a specific substance in a sample.
- Pharmacological test: A pharmacological test is a type of test used to detect, measure, or identify the presence or amount of drugs in a person's body.
- Drug discovery: Drug discovery is the process by which new candidate medications are discovered.
- Biomolecular pathway: A biomolecular pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
See Also
External links
- Medical encyclopedia article on High-throughput screening
- Wikipedia's article - High-throughput screening
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