Human anti-chimeric antibody
Human anti-chimeric antibody
Human anti-chimeric antibody (pronunciation: hyoo-muhn an-tee-ky-mehr-ik an-ti-bod-ee), often abbreviated as HACA, is a type of antibody produced by the human immune system in response to the administration of chimeric monoclonal antibodies.
Etymology
The term "chimeric" is derived from the Greek mythological creature, the Chimera, which was composed of parts of different animals. In the context of antibodies, "chimeric" refers to antibodies that are composed of parts from different species, typically human and mouse. The term "anti-chimeric" refers to the immune response against these chimeric antibodies.
Related Terms
- Monoclonal antibody: A type of antibody made by identical immune cells that are all clones of a unique parent cell.
- Antibody: A large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
- Immune response: The reaction of the cells and fluids of the body to the presence of a substance which is not recognized as a constituent of the body itself.
- Chimera (genetics): An organism or tissue that contains at least two different sets of DNA, most often originating from the fusion of as many different zygotes.
See Also
External links
- Medical encyclopedia article on Human anti-chimeric antibody
- Wikipedia's article - Human anti-chimeric antibody
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