Human equivalent
Human Equivalent
Human Equivalent (pronunciation: /ˈhjuːmən ɪˈkwɪvələnt/) is a term used in various fields of study, including medicine, biology, and pharmacology. It refers to the conversion of a measure used in animal studies to a measure that is applicable to humans.
Etymology
The term "Human Equivalent" is derived from the English words "human", meaning pertaining to or characteristic of people or human beings, and "equivalent", meaning equal in value, amount, function, meaning, etc.
Related Terms
- Animal Model: An animal model is a non-human species used in medical research to obtain information about biology and disease, as it can mimic aspects of human disease.
- Pharmacokinetics: Pharmacokinetics is the study of how a drug is absorbed, distributed, metabolized, and excreted by the body.
- Dose Conversion: Dose conversion is the process of converting a dose that is safe and effective in one species to a dose that is expected to be safe and effective in another species.
Usage in Medicine
In medicine, the term "Human Equivalent" is often used in the context of drug dosing and toxicology. When a new drug is developed, it is typically tested in animal models before it is tested in humans. The dose that is safe and effective in the animal model is then converted to a human equivalent dose (HED) using a formula that takes into account the differences in body surface area between the animal species and humans.
Usage in Biology
In biology, the term "Human Equivalent" can refer to the use of animal models to study human biology and disease. For example, a mouse model might be used to study the human immune system. The results obtained from the mouse model are then translated to a "human equivalent" to provide insights into human biology and disease.
External links
- Medical encyclopedia article on Human equivalent
- Wikipedia's article - Human equivalent
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