Hy's law

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Hy's Law

Hy's Law (pronounced as "high's law") is a medical rule of thumb pertaining to drug-induced liver injury (DILI). It is named after the hepatologist, Hyman Zimmerman, who first proposed the concept.

Etymology

Hy's Law is named after Hyman Zimmerman, a prominent hepatologist who made significant contributions to the understanding of drug-induced liver injury. The term "Hy's Law" was coined to honor his work in this field.

Definition

Hy's Law is defined as an increase in serum alanine aminotransferase (ALT) levels to more than three times the upper limit of normal (ULN), combined with an increase in serum bilirubin levels to more than two times the ULN, in the absence of other causes of liver injury. This pattern of liver enzyme abnormalities is considered a strong predictor of severe, potentially fatal, drug-induced liver injury.

Related Terms

  • Alanine aminotransferase (ALT): An enzyme found primarily in the liver and kidney. It is released into the bloodstream when either of these organs is damaged. High levels of ALT in the blood can indicate liver damage.
  • Bilirubin: A yellow compound that occurs in the normal catabolic pathway that leads to the breakdown of heme in vertebrates. High levels of bilirubin in the blood can indicate liver damage.
  • Drug-induced liver injury (DILI): Liver damage due to drugs or herbal supplements. It is a common cause of acute liver failure.
  • Hepatologist: A specialist in the branch of medicine called hepatology, which focuses on the study of the liver, gallbladder, biliary tree, and pancreas.

See Also

External links

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