From WikiMD
Jump to navigation Jump to search

Information about Hydromorphone

Hydromorphone and oxymorphone are semisynthetic derivatives of morphine and potent opiate agonists which are used predominantly to treat moderate-to-severe pain.

Liver safety of Hydromorphone

Neither hydromorphone nor oxymorphone have been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.

Mechanism of action of Hydromorphone

Hydromorphone and oxymorphone are semisynthetic derivatives that both act by engagement in cell surface opiate receptors (predominant µ type receptors) that are found in the central nervous system, but also heart, lung, vascular and intestinal cells. Current indications are for moderate to severe pain, pre- and postoperative analgesia, and as an adjunct to anesthesia.

FDA approval information for Hydromorphone

Hydromorphone was approved for use in the United States in 1984 and is still widely used in treatment of moderate-to-severe pain and, in low doses, as an antitussive.

Dosage and administration for Hydromorphone

Hydromorphone is available generically and under the brand name Dilaudid as tablets of 2, 4 and 8 mg, as an oral solution of 5 mg/5 mL and as suppositories of 3 mg. Solutions for injection (1 to 10 mg/mL) are also available. The usual dose of hydromorphone in adults is 2 to 10 mg orally every 3 to 6 hours or 2 to 4 mg by injection every 4 to 6 hours. Lower doses (1 mg orally) are used for treatment of cough.

Clinical use of Hydromorphone

Oxymorphone was approved for use in the United States in 1959 and remains in clinical use. Current indications are for treatment of moderate to severe pain, alleviation of anxiety associated with dyspnea of pulmonary edema and as an adjunct to general anesthesia and preoperative sedation. Oxymorphone is available generically and under the brand name Numorphan and Opana in standard tablets of 5 and 10 mg, extended release tablets of 5 to 40 mg, suppositories of 5 mg and as a solution for injection of 1 mg/mL. The usual dose of oxymorphone is 5 to 20 mg orally of the standard tablets every 4 to 6 hours or 1 to 1.5 mg by injection every 4 to 6 hours.

Side effects of Hydromorphone

The side effects of hydromorphone and oxymorphone are similar to those of other opiates and include sedation, respiratory depression, confusion, euphoria, agitation, constipation, abdominal bloating, nausea, vomiting and constipation.

DEA controlled substance classification of Hydromorphone

Both drugs are controlled substances and classified as Schedule II drugs, indicating that it has medical usefulness, but also a high potential for physical and psychological dependency and abuse.

Full and partial opiod agonists:

Opiate antagonists:

Cost and Coupons - Hydromorphone

Reviews for Hydromorphone

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Articles on Hydromorphone

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Hydromorphone

Drug classes

Our sponsors:W8MD weight loss, sleep and medspa

WikiMD Resources for Hydromorphone


Most recent articles

Most cited

Review articles

Articles on Hydromorphone in N Eng J Med, Lancet, BMJ

Media Hydromorphone

Powerpoint slides

Podcasts and MP3's


Evidence Based Medicine

Cochrane Collaboration

Clinical Trials

Ongoing Trials on Hydromorphone

Trial results on Hydromorphone

Clinical Trials on Hydromorphone at Google

Books and news

Books on Hydromorphone

Hydromorphone in the news

Commentary Hydromorphone

Blogs on Hydromorphone

Patient Resources / Community

Patient resources

Discussion groups

Patient Handouts

Other resources

Social Media

YouTube videos

W8MD Weight Loss, Sleep & MedSpa

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z

W8MD logo

Ad. Tired of being overweight?. W8MD's insurance weight loss can HELP*

Lose weight King of Prussia, PA | Lose weight NYC | Lose weight NJ | Lose weight Philadelphia | Advertise

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary for weight loss from our sponsors.

Our sponsors WikiMD is supported by W8MD weight loss, sleep and medical aesthetic centers.