IC50

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IC50

IC50 (pronounced as I-C-fifty) is a term used in pharmacology to denote the half maximal inhibitory concentration of a substance. It is a measure of the effectiveness of a substance in inhibiting a specific biological or biochemical function.

Etymology

The term IC50 is an abbreviation for "Inhibitory Concentration 50%". It is derived from the field of pharmacology, where it is used to measure the potency of a drug in inhibiting a specific biological or biochemical function.

Definition

The IC50 value represents the concentration of a drug that is required for 50% inhibition in vitro. It is commonly used as a measure of antagonist drug potency in pharmacological research. According to the EC50 (half maximal effective concentration) values, the lower the IC50, the more potent the antagonist, with the lowest IC50 value indicating the most potent antagonist.

Calculation

The IC50 value is calculated using the Hill equation, a mathematical formula used in pharmacology to determine the dose-response relationship of drugs. The Hill equation is used to calculate the IC50 value by plotting the response against the logarithm of the dose and fitting the data to a sigmoidal curve.

Related Terms

  • EC50: The concentration of a drug that gives half-maximal response.
  • Ki: The binding affinity of a drug, which is the inverse of the IC50.
  • Hill equation: A mathematical formula used to determine the dose-response relationship of drugs.

See Also

External links

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