Ichthyosis

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Ichthyosis in a child

What is ichthyosis?

Ichthyosis is a variety of diseases in which the skin is dry and scaly. The disease is usually passed down from your parents. Symptoms usually start showing up at about one year of age. The disease affects you throughout life.Ichthyosis is characterized by dry or scaly and thickened skin. “Ichthy” comes from the Greek word for fish. This condition is called “ichthyosis” because the thickened skin sometimes has the appearance of fish scales.

Ichthyosis can be inherited from your parents, in which case it usually appears before your first birthday and affects you throughout life. This information will focus on inherited ichthyosis, although the disease could also occur as the result of some medical problems.

Symptoms of Ichthyosis

The most common signs of ichthyosis are dry scaly skin, redness, blistering, or too much skin shedding. Symptoms include itching, overheating, and pain.

Doctors may identify ichthyosis by the gene that causes it, although symptoms can usually place the disease into one of five categories:

  • Ichthyosis vulgaris: mild skin scaling and dryness.
  • Epidermolytic ichthyosis (previously called epidermolytic hyperkeratisis): thick, often spiny dark scales; injured skin may blister easily.
  • Lamellar ichthyosis: large, platelike scales and thickening of the skin.
  • Congenital ichthyosiform erythroderma: red skin and fine scales.
  • Localized ichthyosis: thick or scaly skin at certain places, such as the palms of the hands and bottoms of the feet.

Causes of Ichthyosis

Ichthyosis may be either inherited or acquired. Inherited ichthyosis is usually apparent during the first year of life, often at birth, and continues to affect a person throughout life. Acquired ichthyosis may occur as the result of medical problems including hormonal, inflammatory, or malignant disorders. This fact sheet focuses on inherited ichthyosis.

There are more than 40 defective genes that can cause ichthyosis. In general, defects in more than one gene cause each clinical type of ichthyosis.

Diagnosis of Ichthyosis

Your doctor diagnoses ichthyosis through a physical exam and by asking you questions about your health. In some cases, doctors may take blood or skin samples to diagnose the condition or identify the particular form.

Treatment of Ichthyosis

There is no cure for ichthyosis. Treatment relieves symptoms and can include creams, lotions, or ointments to relieve dryness. Salt or aspirin dissolved in water, or over-the-counter lotions containing urea, may also ease scaling. For more severe cases, doctors may prescribe certain forms of vitamin A.

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