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Idarubicin
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Clinical data | |
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Other names | 9-acetyl-7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione |
AHFS/Drugs.com | Monograph |
MedlinePlus | a691004 |
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Pharmacokinetic data | |
Protein binding | 97% |
Elimination half-life | 22 hours |
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E number | {{#property:P628}} |
CompTox Dashboard (EPA) |
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ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C26H27NO9 |
Molar mass | 497.494 g/mol g·mol−1 |
3D model (JSmol) | |
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Idarubicin or 4-demethoxydaunorubicin is an anthracycline antileukemic drug. It inserts [1] itself into DNA and prevents DNA unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake.[2] Similar to other anthracyclines, it also induces histone eviction from chromatin.[3]
It belongs to the family of drugs called antitumor antibiotics.
It is currently combined with cytosine arabinoside as a first line treatment of acute myeloid leukemia.
It is used for treatment of acute lymphoblastic leukemia and Chronic myelogenous leukemia in blast crisis.[4]
It is distributed under the trade names Zavedos (UK) and Idamycin (USA).
Side effects
Diarrhea, stomach cramps, nausea and vomiting are common among patients treated with idarubicin.[5]
References
External links
- Idarubicin bound to proteins in the PDB
Latest research - Idarubicin
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