Idarubicin or 4-demethoxydaunorubicin is an anthracycline antileukemic drug. It inserts  itself into DNA and prevents DNA unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake. Similar to other anthracyclines, it also induces histone eviction from chromatin.
It belongs to the family of drugs called antitumor antibiotics.
It is distributed under the trade names Zavedos (UK) and Idamycin (USA).