Indometacin

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Indometacin

Indometacin (pronounced in-doh-MET-uh-sin), also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling. It works by inhibiting the production of prostaglandins, substances in the body that cause inflammation and pain.

Etymology

The term "Indometacin" is derived from the compounds involved in its chemical structure: indole, acetic acid, and amine. It was first synthesized in the 1960s by the pharmaceutical company Merck Sharp & Dohme.

Usage

Indometacin is used to treat moderate to severe osteoarthritis, rheumatoid arthritis, gouty arthritis, and ankylosing spondylitis. It is also used to treat shoulder pain caused by bursitis or tendinitis. Extended-release indometacin and regular indometacin are not equivalent on a milligram-per-milligram basis.

Side Effects

Like other NSAIDs, indometacin can cause various side effects. These may include upset stomach, heartburn, headache, dizziness, and drowsiness. More serious side effects can include high blood pressure, heart failure, kidney problems, and liver problems.

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